※ dbPPT Protein Information
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UniProt Accession | |||||||||||||||||||||||||||||||
Theoretical PI | 4.54 | ||||||||||||||||||||||||||||||
Molecular Weight | 33888.85 | ||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||
Protein Name | ATPase ASNA1 homolog; Arsenical pump-driving ATPase homolog; Arsenite-stimulated ATPase | ||||||||||||||||||||||||||||||
Gene Name | VITISV_018248 | ||||||||||||||||||||||||||||||
Created Date | 2007-06-12 | ||||||||||||||||||||||||||||||
Organism | Vitis vinifera(Grape) | ||||||||||||||||||||||||||||||
NCBI Taxa ID | 29760 | ||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). Sequence Annotation nucleotide phosphate-binding region 28 35 ATP active site 57 binding site 226 ATP binding site 253 ATP Keyword ATP-binding,Cytoplasm,Endoplasmic reticulum,Hydrolase,Metal-binding,Nucleotide-binding,Transport,Zinc Sequence Source UniProt Protein Sequence MASDQELSGT VQNILDQESL KWVFVGGKGG VGKTTCSSIL SILLSRVRSS VLIISTDPAH 60 NLSDAFQQRF TKAPTLVNGF SNLYAMEVDP SVENEELPGD GMDNLFSELA NAIPGIDEAM 120 SFAEMLKLVQ TMDYSVIVFD TAPTGHTLRL LQFPSTLEKG LAKMMSLKNK FGGLLNQMTR 180 LFGVDDEFGE DALLGRLEGM KDVIEQVNKQ FKDPDLTTFV CVCIPEFLSL YETERLVQEL 240 NKFEIDSHNV IINQVLYDEE VVESKLLKAR MRMQQKYLDQ FYMLYDDFHI TKLPLLPEEV 300 D 301 Gene Ontology GO:0005783; C: endoplasmic reticulum; IEA: UniProtKB-SubCell GO:0005524; F: ATP binding; IEA: UniProtKB-HAMAP GO:0016887; F: ATPase activity; IEA: InterPro GO:0046872; F: metal ion binding; IEA: UniProtKB-KW GO:0045048; P: protein insertion into ER membrane; IEA: UniProtKB-HAMAP GO:0006810; P: transport; IEA: UniProtKB-KW Interpro Pfam Pfam; PF02374; ArsA_ATPase SMART PROSITE PRINTS |