※ dbPPT Protein Information
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UniProt Accession | |||||||||||||||||||||||||||||||||||
Theoretical PI | 6.26 | ||||||||||||||||||||||||||||||||||
Molecular Weight | 55565.31 | ||||||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||||||
Protein Name | Adenylosuccinate synthetase 1, chloroplastic; AMPSase 1; AdSS 1; IMP--aspartate ligase 1 | ||||||||||||||||||||||||||||||||||
Gene Name | PURA1; PHYPADRAFT_210943 | ||||||||||||||||||||||||||||||||||
Created Date | 2010-10-05 | ||||||||||||||||||||||||||||||||||
Organism | Physcomitrella patens subsp. patens(Moss) | ||||||||||||||||||||||||||||||||||
NCBI Taxa ID | 3218 | ||||||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Sequence Annotation transit peptide 1 73 Chloroplast chain 74 514 Adenylosuccinate synthetase 1, chloroplastic nucleotide phosphate-binding region 100 106 GTP nucleotide phosphate-binding region 128 130 GTP nucleotide phosphate-binding region 419 421 GTP nucleotide phosphate-binding region 502 504 GTP region of interest 101 104 IMP binding region of interest 126 129 IMP binding region of interest 387 393 Substrate binding active site 101 Proton acceptor active site 129 Proton donor metal ion-binding site 101 Magnesium metal ion-binding site 128 Magnesium; via carbonyl oxygen binding site 218 IMP binding site 232 IMP; shared with dimeric partner binding site 312 IMP binding site 327 IMP binding site 391 IMP binding site 393 GTP Keyword Chloroplast,Complete proteome,GTP-binding,Ligase,Magnesium,Metal-binding,Nucleotide-binding,Plastid,Purine biosynthesis,Reference proteome,Transit peptide Sequence Source UniProt Protein Sequence MAMAAAAAVA SQGLVAASTQ QQKKTSAKLS CNAAPVFSGK SFLRVKSGSN GAVRVRNVGV 60 RCEAQAIERE SVKADTGSGR EEDAFSGLKQ VCAVLGTQWG DEGKGKLVDI LAQRFDVVAR 120 CQGGANAGHT IYNDKGEKFA LHLVPSGILN EKTTCVVGNG VVIHLPGFFK EIDNLESKGV 180 NTSGRLLVSD RAHLLFNLHQ EVDGLREAEL AGQMIGTTKR GIGPCYASKA IRNGIRVGDL 240 RHLDTFREKL DILFRDAAAR FKGFEYSAAA VDAEMEMYVK YAERLEHYIV DTVDYVNTAY 300 AEGKRILIEG GQATMLDIDF GTYPFVTSSN PSVGGICTGL GMAPNRLGDI VGVAKAYTTR 360 VGSGPYPTEL FGEEGEELRK AGFEWGTTTG RPRRCGWLDI VALNFACTIN GFTAINLTKL 420 DVLSGLPEVK LGVAYRTQSG EKLRSFPADL SILEQVEVEY ETLEAWKEDI TKVRSYAELP 480 VAAQKYVERI EELIGLPCQY IGVGPGRDAL IVKQ 514 Gene Ontology GO:0048046; C: apoplast; IEA: EnsemblPlants/Gramene GO:0009570; C: chloroplast stroma; IEA: EnsemblPlants/Gramene GO:0004019; F: adenylosuccinate synthase activity; IEA: UniProtKB-HAMAP GO:0005525; F: GTP binding; IEA: UniProtKB-HAMAP GO:0000287; F: magnesium ion binding; IEA: UniProtKB-HAMAP GO:0044208; P: 'de novo' AMP biosynthetic process; IEA: UniProtKB-UniPathway GO:0046686; P: response to cadmium ion; IEA: EnsemblPlants/Gramene Interpro Pfam Pfam; PF00709; Adenylsucc_synt SMART SMART; SM00788; Adenylsucc_synt PROSITE PRINTS |