※ dbPPT Protein Information
| Tag | Content | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProt Accession | |||||||||||||||||||||||||||||||
Theoretical PI | 6.9 | ||||||||||||||||||||||||||||||
Molecular Weight | 22139.54 | ||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||
Protein Name | Inosine triphosphate pyrophosphatase; ITPase; Inosine triphosphatase; Non-canonical purine NTP pyrophosphatase; Non-standard purine NTP pyrophosphatase; Nucleoside-triphosphate diphosphatase; Nucleoside-triphosphate pyrophosphatase | ||||||||||||||||||||||||||||||
Gene Name | MTR_134s0027 | ||||||||||||||||||||||||||||||
Created Date | 2009-02-10 | ||||||||||||||||||||||||||||||
Organism | Medicago truncatula(Barrel medic Medicago tribuloides) | ||||||||||||||||||||||||||||||
NCBI Taxa ID | 3880 | ||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions (By similarity). Sequence Annotation region of interest 21 26 Substrate binding region of interest 77 78 Substrate binding region of interest 153 156 Substrate binding region of interest 181 182 Substrate binding metal ion-binding site 49 Magnesium or manganese metal ion-binding site 77 Magnesium or manganese binding site 61 Substrate binding site 176 Substrate Keyword Cytoplasm,Hydrolase,Magnesium,Manganese,Metal-binding,Nucleotide metabolism,Nucleotide-binding Sequence Source UniProt Protein Sequence MAAIKSAASG LVLPRPVTFV TGNAKKLEEV RAILGHSIPF QSLKLDLPEL QGEPEDISKE 60 KARLAAIQVK GPVLVEDTCL CFNALKGLPG PYIKWFLQKI GHEGLNNLLM AYDDKSAYAL 120 CVFSFAIGPD SEPITFSGKT LGKIVPPRGP NDFGWDPVFQ PDGYDQTYAE MSKEEKNKIS 180 HRSKSLALVK SHFAEAGYTF QI 202 Gene Ontology GO:0005737; C: cytoplasm; IEA: UniProtKB-SubCell GO:0046872; F: metal ion binding; IEA: UniProtKB-KW GO:0047429; F: nucleoside-triphosphate diphosphatase activity; IEA: UniProtKB-HAMAP GO:0000166; F: nucleotide binding; IEA: UniProtKB-KW GO:0009204; P: deoxyribonucleoside triphosphate catabolic process; IEA: UniProtKB-HAMAP GO:0009117; P: nucleotide metabolic process; IEA: UniProtKB-KW Interpro Pfam Pfam; PF01725; Ham1p_like SMART PROSITE PRINTS |