UniProt Accession

O22582; H2B_GOSHI 

Theoretical PI

10.08 

Molecular Weight

15955.77 

Genbank Protein ID

AF025667 

Genbank Nucleotide ID

AAB97163.1 

Protein Name

Histone H2B 

Gene Name

HIS2B 

Created Date

2000-05-30 

Organism

Gossypium hirsutum(Upland cotton Gossypium mexicanum) 

NCBI Taxa ID

3635 

Phosphorylation Sites

Position	Peptide	Source	References
135	ELAKHAVSEGTKAVT	dbPPT	[1]

Functional Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

initiator methionine 1 Removed
chain 2 147 Histone H2B
modified residue 7 N6-acetyllysine
modified residue 35 N6-acetyllysine
modified residue 36 N6-acetyllysine
cross-link 143 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keyword

Acetylation,Chromosome,DNA-binding,Isopeptide bond,Nucleosome core,Nucleus,Ubl conjugation 

Sequence Source

UniProt 

Protein Sequence

Gene Ontology

GO:0000786; C: nucleosome; IEA: UniProtKB-KW
GO:0005634; C: nucleus; IEA: UniProtKB-SubCell
GO:0003677; F: DNA binding; IEA: UniProtKB-KW
GO:0006334; P: nucleosome assembly; IEA: InterPro 

Interpro

InterPro; IPR009072; Histone-fold
InterPro; IPR007125; Histone_core_D
InterPro; IPR000558; Histone_H2B

Pfam

Pfam; PF00125; Histone 

SMART

SMART; SM00427; H2B 

PROSITE

PS00357; HISTONE_H2B 

PRINTS

PR00621; HISTONEH2B