※ dbPPT Protein Information
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UniProt Accession | |||||||||||||||||||||||||||||||||||
Theoretical PI | 4.61 | ||||||||||||||||||||||||||||||||||
Molecular Weight | 33238.19 | ||||||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||||||
Protein Name | Histone deacetylase HDT1; Histone deacetylase 2a; HD2a; Nucleolar histone deacetylase HD2-p39; Zm-HD2a | ||||||||||||||||||||||||||||||||||
Gene Name | HDT1; HD2a | ||||||||||||||||||||||||||||||||||
Created Date | 2005-08-30 | ||||||||||||||||||||||||||||||||||
Organism | Zea mays(Maize) | ||||||||||||||||||||||||||||||||||
NCBI Taxa ID | 4577 | ||||||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description Mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Able to deacetylate all 4 core histones. Sequence Annotation chain 1 307 Histone deacetylase HDT1 zinc finger region 276 299 C2H2-type; degenerate compositionally biased region 150 196 Asp-rich Keyword Chromatin regulator,Complete proteome,Direct protein sequencing,Hydrolase,Metal-binding,Nucleus,Phosphoprotein,Reference proteome,Repressor,Transcription,Transcription regulation,Zinc,Zinc-finger Sequence Source UniProt Protein Sequence MEFWGLEVKP GSTVKCEPGY GFVLHLSQAA LGESKKSDNA LMYVKIDDQK LAIGTLSVDK 60 NPHIQFDLIF DKEFELSHTS KTTSVFFTGY KVEQPFEEDE MDLDSEDEDE ELNVPVVKEN 120 GKADEKKQKS QEKAVAAPSK SSPDSKKSKD DDDSDEDETD DSDEDETDDS DEGLSSEEGD 180 DDSSDEDDTS DDEEEDTPTP KKPEVGKKRP AESSVLKTPL SDKKAKVATP SSQKTGGKKG 240 AAVHVATPHP AKGKTIVNND KSVKSPKSAP KSGGSVPCKP CSKSFISETA LQAHSRAKMG 300 ASESQVQ 307 Gene Ontology GO:0005730; C: nucleolus; IEA: UniProtKB-SubCell GO:0016787; F: hydrolase activity; IEA: UniProtKB-KW GO:0046872; F: metal ion binding; IEA: UniProtKB-KW GO:0016568; P: chromatin modification; IEA: UniProtKB-KW GO:0006355; P: regulation of transcription, DNA-templated; IEA: UniProtKB-KW GO:0006351; P: transcription, DNA-templated; IEA: UniProtKB-KW Interpro InterPro; IPR007087; Znf_C2H2 Pfam SMART PROSITE PS50157; ZINC_FINGER_C2H2_2 PRINTS |