UniProt Accession

P29557; IF4E1_WHEAT 

Theoretical PI

5.39 

Molecular Weight

23990.61 

Genbank Protein ID

Z12616 

Genbank Nucleotide ID

CAA78262.2 

Protein Name

Eukaryotic translation initiation factor 4E-1; eIF-4E-1; eIF4E-1; eIF-4F 25 kDa subunit; eIF-4F p26 subunit; mRNA cap-binding protein 

Gene Name

 

Created Date

1993-04-01 

Organism

Triticum aestivum(Wheat) 

NCBI Taxa ID

4565 

Phosphorylation Sites

Position	Peptide	Source	References
11	DTETRPASAGAEERE	dbPPT	[1]

Functional Description

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. 

Sequence Annotation

chain 1 215 Eukaryotic translation initiation factor 4E-1
disulfide bond 113 151
strand 41 51
strand 59 61
strand 64 66
strand 69 74
helix 75 82
helix 88 90
strand 96 101
helix 102 104
turn 112 115
strand 117 123
helix 129 140
helix 147 149
strand 150 157
strand 162 169
helix 174 188
strand 195 198
helix 199 203
strand 206 208
strand 212 214

Keyword

3D-structure,Complete proteome,Direct protein sequencing,Disulfide bond,Initiation factor,Protein biosynthesis,RNA-binding,Translation regulation 

Sequence Source

UniProt 

Protein Sequence

Gene Ontology

GO:0005737; C: cytoplasm; IEA: InterPro
GO:0003743; F: translation initiation factor activity; IEA: UniProtKB-KW
GO:0006417; P: regulation of translation; IEA: UniProtKB-KW 

Interpro

InterPro; IPR023398; TIF_eIF4e-like_dom
InterPro; IPR001040; TIF_eIF_4E
InterPro; IPR019770; TIF_eIF_4E_CS

Pfam

Pfam; PF01652; IF4E 

SMART

 

PROSITE

PS00813; IF4E 

PRINTS