※ dbPPT Protein Information
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UniProt Accession | |||||||||||||||||||||||||||||||||||
Theoretical PI | 9.12 | ||||||||||||||||||||||||||||||||||
Molecular Weight | 47612.74 | ||||||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||||||
Protein Name | Cyclin-dependent kinase D-1; CDKD;1; CDC2+/CDC28-related protein kinase R2; CDK-activating kinase R2; CAK-R2 | ||||||||||||||||||||||||||||||||||
Gene Name | CDKD-1; R2; Os05g0392300; LOC_Os05g32600; OJ1764_D01.12 | ||||||||||||||||||||||||||||||||||
Created Date | 1993-04-01 | ||||||||||||||||||||||||||||||||||
Organism | Oryza sativa subsp. japonica(Rice) | ||||||||||||||||||||||||||||||||||
NCBI Taxa ID | 39947 | ||||||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description CDK-activating kinase that may control G1/S phase progression. May control the rate of cell differentiation to accomplish proper development of organs, or in response to a changing environment. Forms a complex with cyclin CYCH1-1 that phosphorylates CDKA-1 and the C-terminal domain (CTD) of the large subunit of RNA polymerase II. Sequence Annotation chain 1 424 Cyclin-dependent kinase D-1 domain 19 299 Protein kinase nucleotide phosphate-binding region 25 33 ATP active site 141 Proton acceptor binding site 48 ATP modified residue 29 Phosphothreonine modified residue 30 Phosphotyrosine modified residue 168 Phosphoserine modified residue 174 Phosphothreonine Keyword ATP-binding,Cell cycle,Cell division,Complete proteome,Kinase,Nucleotide-binding,Nucleus,Phosphoprotein,Reference proteome,Serine/threonine-protein kinase,Transferase Sequence Source UniProt Protein Sequence MASGDGGDDA GVKRVADRYL KREVLGEGTY GVVFKAVDTK TGNTVAIKKI RLGKYKEGVN 60 FTALREIKLL KELKDSNIIE LIDAFPYKGN LHLVFEFMET DLEAVIRDRN IVLSPADTKS 120 YIQMMLKGLA FCHKKWVLHR DMKPNNLLIG ADGQLKLADF GLARIFGSPE RNFTHQVFAR 180 WYRAPELLFG TKQYGSAVDI WAAGCIFAEL LLRRPFLQGS SDIDQLGKIF AAFGTPKSSQ 240 WPDMVYLPDY VEYQFVSAPP LRSLFPMASD DALDLLSRMF TYDPKARITA QQALEHRYFL 300 SVPAPTKPSQ LPRPPPKGDS GNNKIPDLNL QDGPVVLSPP RKLRRVTAHE GMEVHMHRAD 360 RTEEHPSGAR HMDDMSSQSS RIPMSVDVGA IFGTRPAPRP TLNSADKSRL KRKLDMDPEF 420 GYTE 424 Gene Ontology GO:0005634; C: nucleus; IEA: UniProtKB-SubCell GO:0005524; F: ATP binding; IEA: UniProtKB-KW GO:0004693; F: cyclin-dependent protein serine/threonine kinase activity; IEA: UniProtKB-EC GO:0008353; F: RNA polymerase II carboxy-terminal domain kinase activity; IEA: UniProtKB-EC GO:0051301; P: cell division; IEA: UniProtKB-KW Interpro Pfam Pfam; PF00069; Pkinase SMART SMART; SM00220; S_TKc PROSITE PRINTS |