※ dbPPT Protein Information
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UniProt Accession | |||||||||||||||||||||||||||||||||||
Theoretical PI | 5.31 | ||||||||||||||||||||||||||||||||||
Molecular Weight | 46927.65 | ||||||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||||||
Protein Name | Eukaryotic initiation factor 4A; eIF-4A; ATP-dependent RNA helicase eIF4A | ||||||||||||||||||||||||||||||||||
Gene Name | |||||||||||||||||||||||||||||||||||
Created Date | 1995-11-01 | ||||||||||||||||||||||||||||||||||
Organism | Triticum aestivum(Wheat) | ||||||||||||||||||||||||||||||||||
NCBI Taxa ID | 4565 | ||||||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Sequence Annotation chain 1 414 Eukaryotic initiation factor 4A domain 72 242 Helicase ATP-binding domain 253 414 Helicase C-terminal nucleotide phosphate-binding region 85 92 ATP short sequence motif 41 69 Q motif short sequence motif 190 193 DEAD box Keyword ATP-binding,Complete proteome,Helicase,Hydrolase,Initiation factor,Nucleotide-binding,Protein biosynthesis,RNA-binding Sequence Source UniProt Protein Sequence MAGMAPEGSQ FDAKNYDSKM QELLSQGETE EFFTSYDEVH ESFDDMGLQE NLLRGIYAYG 60 FEKPSAIQQR GIVPFCKGLD VIQQAQSGTG KTATFCSGIL QQLDYGLVEC QALVLAPTRE 120 LAQQIEKVMR ALGDYLGVKV HACVGGTSVR EDQRILASGV HVVVGTPGRV FDIVRRQSLR 180 PDNIKMFVLD EADEMLSRGF KDQIYDIFQL LPGKIQVGVF SATMPPEALE ITRKFMNKPV 240 RILVKRDELT LEGIKQFYVN VEKEEWKLDT LCDLYETLAI TQSVIFVNTR RKVDWLTDKM 300 RGRDHTVSAT HGDMDQNTRD IIMREFRSGS SRVLITTDLL ARGIDVQQVS LVINYDLPTQ 360 PENYQHRIGR SGRFGRKGVA INFVTREDER MLFDIQKFYN VVIEELPANV ADLL 414 Gene Ontology GO:0005524; F: ATP binding; IEA: UniProtKB-KW GO:0008026; F: ATP-dependent helicase activity; IEA: InterPro GO:0003743; F: translation initiation factor activity; IEA: UniProtKB-KW Interpro Pfam SMART PROSITE PRINTS |