UniProt Accession

P48599; Q7F2S7; IF4E1_ORYSJ 

Theoretical PI

5.8 

Molecular Weight

25465.33 

Genbank Protein ID

AP003448;U34597 

Genbank Nucleotide ID

BAB85343.1;AAB40348.1 

Protein Name

Eukaryotic translation initiation factor 4E-1; eIF-4E-1; eIF4E-1; eIF-4F 25 kDa subunit; eIF-4F p26 subunit; mRNA cap-binding protein 

Gene Name

Os01g0970400; LOC_Os01g73880; OJ1656_A11.43 

Created Date

1996-02-01 

Organism

Oryza sativa subsp. japonica(Rice) 

NCBI Taxa ID

39947 

Phosphorylation Sites

Position	Peptide	Source	References
7	*MAEEHETRPPSAGR	dbPPT, P3DB	[1, 2]
11	EHETRPPSAGRPPSS	dbPPT, P3DB	[1, 2]
17	PSAGRPPSSGRGRAD	dbPPT, P3DB	[1, 2]

Functional Description

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. 

Sequence Annotation

chain 1 227 Eukaryotic translation initiation factor 4E-1
disulfide bond 125 163

Keyword

Complete proteome,Disulfide bond,Initiation factor,Protein biosynthesis,Reference proteome,RNA-binding,Translation regulation 

Sequence Source

UniProt 

Protein Sequence

Gene Ontology

GO:0005737; C: cytoplasm; IEA: InterPro
GO:0005730; C: nucleolus; IEA: EnsemblPlants/Gramene
GO:0003743; F: translation initiation factor activity; IEA: UniProtKB-KW
GO:0006417; P: regulation of translation; IEA: UniProtKB-KW
GO:0009615; P: response to virus; IEA: EnsemblPlants/Gramene 

Interpro

InterPro; IPR023398; TIF_eIF4e-like_dom
InterPro; IPR001040; TIF_eIF_4E
InterPro; IPR019770; TIF_eIF_4E_CS

Pfam

Pfam; PF01652; IF4E 

SMART

 

PROSITE

PS00813; IF4E 

PRINTS