UniProt Accession

Q2QPG9; Q0IMX6; H2AXB_ORYSJ 

Theoretical PI

10.2 

Molecular Weight

14339.45 

Genbank Protein ID

DP000011;AP008218;AK121752 

Genbank Nucleotide ID

ABA98778.1;BAF29939.1 

Protein Name

Probable histone H2AXb 

Gene Name

Os12g0530000; LOC_Os12g34510 

Created Date

2006-06-13 

Organism

Oryza sativa subsp. japonica(Rice) 

NCBI Taxa ID

39947 

Phosphorylation Sites

Position	Peptide	Source	References
135	KADIGSASQEF****	dbPPT, P3DB	[1, 2]
133	KDKADIGSASQEF**	dbPPT, P3DB	[1, 2]

Functional Description

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation (By similarity). 

Sequence Annotation

chain 1 138 Probable histone H2AXb
short sequence motif 135 136 [ST]-Q motif
modified residue 135 Phosphoserine; by ATM and ATR

Keyword

Chromosome,Complete proteome,DNA-binding,Nucleosome core,Nucleus,Phosphoprotein,Reference proteome 

Sequence Source

UniProt 

Protein Sequence

Gene Ontology

GO:0000786; C: nucleosome; IEA: UniProtKB-KW
GO:0005634; C: nucleus; IEA: UniProtKB-SubCell
GO:0003677; F: DNA binding; IEA: UniProtKB-KW
GO:0006334; P: nucleosome assembly; IEA: InterPro 

Interpro

InterPro; IPR009072; Histone-fold
InterPro; IPR007125; Histone_core_D
InterPro; IPR002119; Histone_H2A

Pfam

Pfam; PF00125; Histone 

SMART

SMART; SM00414; H2A 

PROSITE

PS00046; HISTONE_H2A 

PRINTS

PR00620; HISTONEH2A