※ dbPPT Protein Information
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UniProt Accession | |||||||||||||||||||||||||||||||
Theoretical PI | 5.32 | ||||||||||||||||||||||||||||||
Molecular Weight | 85646.83 | ||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||
Protein Name | Two pore calcium channel protein 1; Voltage-dependent calcium channel protein TPC1; TaTPC1 | ||||||||||||||||||||||||||||||
Gene Name | TPC1 | ||||||||||||||||||||||||||||||
Created Date | 2008-07-01 | ||||||||||||||||||||||||||||||
Organism | Triticum aestivum(Wheat) | ||||||||||||||||||||||||||||||
NCBI Taxa ID | 4565 | ||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the plasma membrane that mediates sucrose-induced Ca(2+) influx in autotrophically grown leaf cells. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Plays a regulatory role in defense responses. Sequence Annotation chain 1 742 Two pore calcium channel protein 1 topological domain 1 82 Cytoplasmic transmembrane region 83 103 Helical; Name=S1 of repeat I; topological domain 104 140 Extracellular transmembrane region 141 161 Helical; Name=S2 of repeat I; topological domain 162 176 Cytoplasmic transmembrane region 177 197 Helical; Name=S3 of repeat I; topological domain 198 204 Extracellular transmembrane region 205 226 Helical; Voltage-sensor; Name=S4 of repeat I; transmembrane region 227 247 Helical; Name=S5 of repeat I; topological domain 248 258 Extracellular intramembrane region 259 273 Pore-forming; Name=Pore-forming 1 topological domain 274 296 Extracellular transmembrane region 297 317 Helical; Name=S6 of repeat I; topological domain 318 446 Cytoplasmic transmembrane region 447 467 Helical; Name=S1 of repeat II; topological domain 468 480 Extracellular transmembrane region 481 501 Helical; Name=S2 of repeat II; topological domain 502 510 Cytoplasmic transmembrane region 511 531 Helical; Name=S3 of repeat II; topological domain 532 540 Extracellular transmembrane region 541 558 Helical; Voltage-sensor; Name=S4 of repeat II; topological domain 559 582 Cytoplasmic transmembrane region 583 603 Helical; Name=S5 of repeat II; topological domain 604 627 Extracellular intramembrane region 628 642 Pore-forming; Name=Pore-forming 2 topological domain 643 663 Extracellular transmembrane region 664 684 Helical; Name=S6 of repeat II; topological domain 685 742 Cytoplasmic domain 335 370 EF-hand 1 domain 376 411 EF-hand 2 compositionally biased region 673 678 Poly-Leu glycosylation site 469 N-linked (GlcNAc...) Keyword Calcium,Calcium channel,Calcium transport,Complete proteome,Glycoprotein,Ion channel,Ion transport,Membrane,Plant defense,Repeat,Transmembrane,Transmembrane helix,Transport,Voltage-gated channel Sequence Source UniProt Protein Sequence MSEAEAPLIT EEAAERGLAS SGSRRLSDGA GGQGSRKYRR RSDALAYGDR YQKAAALVDL 60 AEDGVGIPED VLNDTRFGRA MSFYFVYLRL DWLWSLNLFA LILLNFLEKP LWCRKDALQA 120 YDQRDLYFLG QLPYFSKTES LIYEGLTLVI LVMDIFCPLS YEGLNIFWRS TTNKLKIVLL 180 FILACDILVF AFSSQPFRLA PYIRVVFLIM TIRELRMCAI TLAGLIGTYL NVLALSLLFL 240 LFASWLAYVT FEDTPQGKTI FSSYGVTLYQ MFVLFTTSNN PDVWVHAYKI PRWYSLFFIV 300 YVLLGVYFLT NLILAVIYDS FKEQFAKQLV QVDSIRKNIL QKAFDLIDTN NRGYLDREQC 360 ISLLNELNKY RSLPKTSRED FELIFAELDR SGDFKVTSEE FADLCNTIAI KFQKEPPPSY 420 LEKFPFYHSP LCGRLKSFVR SRMFEYIIVF VLLINLVAVI IETTLDIENS SSQETWQEVE 480 FFLGWIYVAE MALKIFSLGF GAYWMEGQNK FDFVLTWTIF IGETLTFAFP SKLPFLSNGE 540 WIRYLLLGRV LRLTRILLQV QRFRAFVATF FTLMSSLMPY LGIVFCVLCM YCSIGLQIFG 600 GIVYAGNPTL EETDLFNNDY LLFNFNDYPS GMVTLFNLLV MGNWQVWMES YWQLTGTSWS 660 LIYFVSFYLI SILLLLNLIV AFVLEAFFAE MELEKGEEVD IQNPTSGGIK KRRSMRVRSK 720 GTMVDILLHH MLSNELDGSQ NS 742 Gene Ontology GO:0016021; C: integral component of membrane; IEA: UniProtKB-KW GO:0005262; F: calcium channel activity; IEA: UniProtKB-KW GO:0005509; F: calcium ion binding; IEA: InterPro GO:0005244; F: voltage-gated ion channel activity; IEA: UniProtKB-KW GO:0006952; P: defense response; IEA: UniProtKB-KW Interpro Pfam SMART SMART; SM00054; EFh PROSITE PS50222; EF_HAND_2 PRINTS |