※ dbPPT Protein Information
| Tag | Content | ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProt Accession | |||||||||||||||||||||||||||||||
Theoretical PI | 6.03 | ||||||||||||||||||||||||||||||
Molecular Weight | 52655.82 | ||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||
Protein Name | Inosine-5'-monophosphate dehydrogenase; IMP dehydrogenase; IMPD; IMPDH | ||||||||||||||||||||||||||||||
Gene Name | OSJNBa0091J19.1; LOC_Os03g56800 | ||||||||||||||||||||||||||||||
Created Date | 2001-06-01 | ||||||||||||||||||||||||||||||
Organism | Oryza sativa subsp. japonica(Rice) | ||||||||||||||||||||||||||||||
NCBI Taxa ID | 39947 | ||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity). Sequence Annotation domain 167 226 CBS nucleotide phosphate-binding region 263 265 NAD nucleotide phosphate-binding region 313 315 NAD region of interest 353 355 IMP binding region of interest 376 377 IMP binding region of interest 400 404 IMP binding active site 320 Thioimidate intermediate metal ion-binding site 315 Potassium; via carbonyl oxygen metal ion-binding site 317 Potassium; via carbonyl oxygen metal ion-binding site 320 Potassium; via carbonyl oxygen binding site 318 IMP binding site 428 IMP Keyword CBS domain,Complete proteome,Cytoplasm,GMP biosynthesis,Metal-binding,NAD,Oxidoreductase,Potassium,Purine biosynthesis,Reference proteome Sequence Source UniProt Protein Sequence MAASSADLAD DGFPAPRLFS QGVSYTYDDV IFLPGYIGFP ADAVDLSTRL SRRIPLSIPC 60 VASPMDTVSE AAMAAAMASL GAAAVVHCNT EPHLQASIVR AAKSRRLPFV SSVPLFSPAS 120 TPSLSDFAGH DYGLVTERGD SLSKLVGVAV AAETSSRQAP LPVSEYMRPA PRSVSASFDF 180 EQAAAFLADE GLDYAPLVSD DSEVIDLITV NDVERIRSYP KLGKPSLGAD GKFVVAASIG 240 TREDDKRRLE QLVKAGANAI VVDSSQGNSI YQIDMIKYAK KMYPEVDLIG GNVVTIAQAQ 300 NLVASGVDGL RVGMGSGSIC TTQEVCAVGR GQATAVYKVA SYAKDHNVPV IADGGISNSG 360 HIVKALSLGA STVMMGSFLA GSHEAPGTYE YKDGHRVKKY RGMGSLEAMT KGSDARYLGD 420 TLKLKVAQGV VGAVADKGSV LRFIPYTMQA VKQGFQDLGA SSLQSAHELL RSETIKLEVR 480 TGAAQVEGGI HGLVSYEKKA F 501 Gene Ontology GO:0005829; C: cytosol; IEA: EnsemblPlants/Gramene GO:0030554; F: adenyl nucleotide binding; IEA: InterPro GO:0003938; F: IMP dehydrogenase activity; IEA: UniProtKB-HAMAP GO:0046872; F: metal ion binding; IEA: UniProtKB-HAMAP GO:0006177; P: GMP biosynthetic process; IEA: UniProtKB-HAMAP Interpro Pfam Pfam; PF00478; IMPDH SMART SMART; SM00116; CBS PROSITE PRINTS |