※ dbPPT Protein Information
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UniProt Accession | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Theoretical PI | 5.29 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Weight | 507201.89 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Protein Name | Dynein-1-alpha heavy chain, flagellar inner arm I1 complex; 1-alpha DHC; Dynein-1, subspecies f | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Name | DHC1; IDA1; PF9 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Created Date | 2003-05-09 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Organism | Chlamydomonas reinhardtii(Chlamydomonas smithii) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
NCBI Taxa ID | 3055 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for assembly of the I1 inner arm complex and its targeting to the appropriate axoneme location. Also required for phototaxis. Sequence Annotation chain 1 4625 Dynein-1-alpha heavy chain, flagellar inner arm I1 complex nucleotide phosphate-binding region 960 967 ATP nucleotide phosphate-binding region 1958 1965 ATP nucleotide phosphate-binding region 2242 2249 ATP nucleotide phosphate-binding region 2588 2595 ATP nucleotide phosphate-binding region 2945 2952 ATP nucleotide phosphate-binding region 3680 3687 ATP region of interest 1 1919 Stem region of interest 1920 2141 AAA 1 region of interest 2201 2437 AAA 2 region of interest 2550 2800 AAA 3 region of interest 2906 3155 AAA 4 region of interest 3192 3494 Stalk region of interest 3542 3773 AAA 5 region of interest 3998 4216 AAA 6 coiled-coil region 1227 1259 coiled-coil region 1339 1409 coiled-coil region 3192 3297 coiled-coil region 3400 3494 coiled-coil region 3701 3788 Keyword ATP-binding,Cell projection,Cilium,Cilium biogenesis/degradation,Coiled coil,Cytoplasm,Cytoskeleton,Dynein,Flagellum,Microtubule,Motor protein,Nucleotide-binding,Repeat Sequence Source UniProt Protein Sequence MDRRLEWVKE KACLGLGVEP NLFEAAIANP ESRARVTAFL DGTVTSSALL FALEEATIYV 60 EEYQEVLAEE QAPEAEDGEG EEHDGQEPGE AGGEGAEGST APGDSGDGQP EDAPAAAAEA 120 NGANPEDEAA APADGAADGA AGEGGEEGDG AEGDEPPAPP APKYVRRVIS VPKVVSKLNV 180 ALGSLPEELS VFPVFYFILN RSGHVAAEEL DSAVEFGLLS EGPSLRILEQ MLSSVFVPIL 240 VQMSGGDVAS GGVLMQSMTD NSHRELLGNM QKFHSQVTQA LQQLTGDVTL QLPDFPLEDM 300 DRAAADTDLV MQLEQYMAEW SQVLASVLQR ESQKHPTGKG PLAEIEFWRE RNAVLSSLYE 360 QLNLPQVKRM ILVVEKGSDD RNLMAGFKSQ LGELTKLATE ARDNVKFLTT LERHFKNIAT 420 GPLGGILDTL PPMMNALRMV WIISRHYSDD QRMGSLFQRI AREIGDRVEA AVDLRHIFRM 480 TSADAVELLK VCKSVLEHWL QTYMAMREKI ELSGRDARWE FPKQLLFART NYMAEICTDL 540 IEMVEIVDDF FRFLGPELKT VTGDTAGIDR VVHRVVAMYE PIESISFNVF DYGNQHEWKA 600 AKQQFYADNE DIKEATRELI DTSFRKLRSA EGACELLQSF KSIKSKGAIQ KQVMNKFNDI 660 LEQFAREIEQ TADIFERNKD APPVTKNQPP VAGAIKWVRS LLERLKRTMA KLLSTEEEII 720 RTTELGQAVE SKFKSFARSV MLTEKKWFSS WSDSINGVAM QHLKQTIFRR SAATNRVEVN 780 FHPDLVRLIR ETRYLDRMGF PIPEIALNVA LQEDKFLQWL EGLNSMLFKY YESIDQLTPV 840 ERELMERKLE ELESCLQPGF TILNWNSLGI TEFIGTCDKA IATFQQLVKQ VQKNSGIIEQ 900 VVYAIAGAQL VTEPEEGAEV MDLQEFYEDI ERQRLAALES LVKKYRTISP LLGKIEEVVA 960 GTNSGKSPAL SSYYSFWERA IFNALNTMVL CAMTKLQDMI EQRSKHAEGG RKPPLFKVTV 1020 SLQSVDVVVQ PPMTEVNKAL GRLVRSLVES TKAFVRWMDG TCVETPEQRG ATDDDEPIVF 1080 TFYWDVAANP QVIKTMLNLN QSIQRAITSV NKYAESWRRH QALWKTDKNS VLDKFKARDP 1140 SAAQFEDKLS KYAKMATEIS AQAKDFDQDF IRVSCHALAS SVCDEAQAWV RAIAQTMREL 1200 DAVTESQLRD KIAKYQTALH RPPDTLEELK QVLNTVNTIR GESMVMELRY ADLEERYRTR 1260 LLYATNPEEE SQCAHELASA SQVRALWTEL LNEAEAVDWS LEETKKKFSE TTRSQVSDFA 1320 AITAELWEKF RTTGPGLPTV ELASGLDELH KYESNLADAL RQREQLVLAE KLFGMEITAY 1380 PELAQLESEI RKLAQVYGVY AEHAEAVRQY GGQLWSELDV GKMMAGTEAI LTKLRKLKSL 1440 KLLPVYELVE KEIQGFYNSL PLMKELKSEA LRKRHWTRLM EVTGQEFDMD PKTFTLGNMF 1500 AMQLHKYAEE IGKITNAAVK ELTIESEIRK LADVWREQRF ELGKYMKGPE DRGWVLRSTE 1560 DILVLLEDMG LNLQSMMASP FVRPFLTEVR AWEQKLSLIG ECIEVWMHVQ RKWMYLESIF 1620 VGSDDIRHQL PAEAKRFDNI DRQWQKIMND TAKNTVVLDA CMADGRLDLL KSLSEQLEVC 1680 QKSLSEYLDT KRCAFPRFYF ISDDELLSIL GTSDPTSVQE HMLKLFDNCA ALVFGRGNKT 1740 ITGMVSSEKE GFEFRNVVPI EGAVELWMTN VEAEMRKTLY QITKEGIFFY AKTPRTKWIS 1800 ENLGMVTLVG SQIWWTWETE DVFRRVRDGN KHSMKEFAAK LTGQLSELTS MVRSDLSNEV 1860 RKKVNTLIII DVHARDIIDT YVRDSIVDAR EFAWESQLRF YWDRQQDDIL IRQCTGLFKY 1920 GYEYMGLNGR LVITALTDRC YMTLTTALTY RLGGAPAGPA GTGKTETTKD LAKSMALLCV 1980 VFNCGEGLDY KAMGSIFSGL VQCGAWGCFD EFNRIEAEVL SVVSSQIKNI QEALKNDLTR 2040 FQFEGKEISI DPRTGIFITM NPGYAGRTEL PDNLKALFRP VTMVVPDLEQ ICEIMLFSEG 2100 FDSAKVLAKK MTVLYKLSRE QLSKQHHYDF GLRALKSVLV MAGSLKRGAP DMSEQLVLMR 2160 ALRDMNLPKF IFDDVPLFLG LINDLFPGMD CPRVRYPQFN DVVEADLADQ GFKVLTEPSE 2220 QVDKVVQLYE VMMTRHTTMV VGQTGGGKTV ILNTLARAQT KLGKKTHLYT INPKAISVAE 2280 LYGVLDKDTR DWTDGLLSNI FREMNKPLPA ERDEARYLVF DGDVDAVWVE NMNSVMDDNK 2340 LLTLPNGERI RLQNHCKLLF EVFDLQYASP ATISRCGMVY VDSRNLGYKP YIYTWLNSRA 2400 KQAEVDILRG LFEKYAVPSV DWILEGIDGE ELVRRPKQAV PVTNLNMITQ LCNLLNATIT 2460 DHPRMSDPQI LEAIFIFCTI WSLGAAIVQR PESPDRDRFD AFVKHIASMG LVDGERVAAT 2520 QLPARSLYEY CFDTNEGVWK SWRSYLQPYE PPADGAFAKI LVPTVDVVRS TWLLNTVVAA 2580 GKPCLFVGES GTAKSVTIAN YLAHLDSTIN IVLNVNFSSR TSSLDVQRAI EDSTEKRTKD 2640 TYGPPMGKRL LMFIDDLNMP RVDTYGTQQP IALLKLFIER KGLYDRGKEL SWKNMKDVQV 2700 VGAMGPPGGA RNPVDPRFIS LFSVFEIQFP SNENLRTIYQ AILSRHLAKL PTDEIRDQLG 2760 ERLTDVTLEL YNFIIDKLPP TPSRFHYIFN LRDLSRIYEG LLLTVGDVFK TPEQFLRLWR 2820 NECLRVLHDR LISTDDKRVM TERLEALVQQ KFPNLAAHTL ASPVLFGDFK NVINELQGEG 2880 EVAPRMYDDL GDYNSIKPLF EDVMTNFYNR KRKPMNLVFF EDALEHLTRI HRTLRLPQGN 2940 CLLVGVGGSG KQSLSKLAAF TAGCEVFEIT LTRGYDELAF REDLKRLYAM LGSDNKRVMF 3000 LFTDAHVADE GFLELINNML TSGMVPALYD GAEKDGLIGS VRAEVEKKGL LATKESCWSY 3060 YVDKCRNNLH VVLAMSPVGE TLRSRCRNFP GMVNNTVIDW FEPWPEQALT SVASVFLAEE 3120 ALPEALRPQI VEHMVTVHQS VRTFSTRFLE ELRRYNYVTP KNYLDFINNY KRALATNRRT 3180 IEDTVTRLSG GLEKLIQAAV EVDAMQKELS QAQVVVAQAT KECNELLEVI STNTVDVETK 3240 AKAAAIKEAQ LKVDSEQIAI EKAEAEAALE EAIPALEEAA AALQDLSKDH ITEIRSYAKP 3300 PEQVQKVCEC VVILRNIKDV SWLGAKSMMA DGNFLRSLVE FDKDSLTDKQ VKKVKEYFKD 3360 PKAPLTYDSL RAISTAGAGL LKWVLAMVNY NNVARTVEPK RKKVAESEKN LRIAQKDLAS 3420 TKLELQSLND QLGKLRTQFE EKTAEQQDLK AKADLMERRL IAASKLIAGL GSERERWTRD 3480 IADLESRRDR LIGDCLLTSS FLSYTGAFTA TYRHAMVYEM WQDDVKARGV PVTQPFRLEA 3540 LLTSDVETTG WASEGLPSDE LSIQNGILTV RANRWPLCID PQMQAVNWIK SREGKMLEGK 3600 VKTFNDSDFL KQLELSIQYG FPFLFENLDE YIDPVIDPVL EKNLVPGDGK FVIKLGDKEV 3660 EWDSNFRLYM TSKLSNPHYG PEISGKTMII NYGVTQQGLT EQLLNVTLRH ERSDLEEARE 3720 ALIKQMSENK ATLQALEDTL LRELSNAQGN ILDNSELIAT LESAKLKAVE IAEKLEASKV 3780 TAAEIEETRV RYSPAAKRGA ILFFVIAGLS AITNMYEYSL ASFLVVFNGS LHSSRRDASI 3840 EGRLRNIIDT LTYDVYAYTC LGLFERHKLM FSFQMTCKIL EGDTPLDPQL LDFFLKGNLS 3900 LEKAARRKPF DWFPDAGWQD LMRLVELGQK KIGADGRMHA LGSLANDVES DEAAWRTWYD 3960 LEAPEEAELP CGYQSFLSDF EKLCLMRCLR MDRVTVGITR FVIGVMGEKY VQPPVLEYRS 4020 IYKQSTETTP IVFVLSPGAD PAFDVFKLGE EMGFRPGAKL KYMALGQGMG PKAQELIETG 4080 ATRGLWIMLQ NCHLLPTWLK TLEKILEKIT KPHADFRLWL TTELTDRFPL GVLQRSLKVV 4140 TEPPNGLKLN MRQSYSKITE EVLADCPHQA FRPLVYVLGF FHAVVQERRK YGKLGWNVPY 4200 DFNETDFRIS MALISTYLTK AWDAQDDLIP WGTLRYLIGE AMYGGRVSDS YDRRILTTYL 4260 DEYLGDFLFD TFQPFRFYAC KDYEIAIPQT GSRDTYLKAV EALPLVQSPE AFGLNANADI 4320 SYYTSATKAI WTDLVDLQPR TGGGGGGVAR EEFIGGVARD IAAKIPEPFD LPQLRKELGT 4380 PSPTQVVLLQ ELERWNSVLG VMVSSLRDLQ RALSGEIGFS SRLEELASSL YNGKLPAMWA 4440 RLNPATEKAL GAWMLWFGRR YRQYKDWTEH GEPKVIWLSG LHIPETYIAA LVQAACRDKG 4500 WPLDKSTLYT KVTKFTDPYQ VSERPKYGCY MSGLYLEGAA WDLEASQLRK QDPKVLVNEL 4560 PILQVIPIEA NKLKLANTFR APVYVTQARR NAMGVGLVFD ADLASAEHSS HWVLQGVALV 4620 LNIDQ 4625 Gene Ontology GO:0005930; C: axoneme; IEA: InterPro GO:0030286; C: dynein complex; IEA: UniProtKB-KW GO:0005874; C: microtubule; IEA: UniProtKB-KW GO:0005524; F: ATP binding; IEA: UniProtKB-KW GO:0016887; F: ATPase activity; IEA: InterPro GO:0003777; F: microtubule motor activity; IEA: InterPro GO:0030030; P: cell projection organization; IEA: UniProtKB-KW GO:0007018; P: microtubule-based movement; IEA: InterPro Interpro InterPro; IPR003593; AAA+_ATPase InterPro; IPR011704; ATPase_dyneun-rel_AAA InterPro; IPR026983; DHC_fam InterPro; IPR024743; Dynein_HC_stalk InterPro; IPR024317; Dynein_heavy_chain_D4_dom InterPro; IPR004273; Dynein_heavy_dom InterPro; IPR013594; Dynein_heavy_dom-1 InterPro; IPR013602; Dynein_heavy_dom-2 InterPro; IPR027417; P-loop_NTPase Pfam SMART SMART; SM00382; AAA PROSITE PRINTS |