※ dbPPT Protein Information
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UniProt Accession | |||||||||||||||||||||||||||||||||||||||||||||||
Theoretical PI | 8.12 | ||||||||||||||||||||||||||||||||||||||||||||||
Molecular Weight | 54711.14 | ||||||||||||||||||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||||||||||||||||||
Protein Name | 3-phosphoinositide-dependent protein kinase 1; AtPDK1 | ||||||||||||||||||||||||||||||||||||||||||||||
Gene Name | PDPK1; PDK1; At5g04510; T32M21.110 | ||||||||||||||||||||||||||||||||||||||||||||||
Created Date | 2010-11-02 | ||||||||||||||||||||||||||||||||||||||||||||||
Organism | Arabidopsis thaliana(Mouse-ear cress) | ||||||||||||||||||||||||||||||||||||||||||||||
NCBI Taxa ID | 3702 | ||||||||||||||||||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description May couple lipid signals to the activation-loop phosphorylation of several protein kinases of the so-called AGC kinase family. Interacts via its pleckstrin homology domain with phosphatidic acid, PtdIns3P and PtdIns(3,4)P2 and to a lesser extent with PtdIns(4,5)P2 and PtdIns4P. May play a general role in signaling processes controlling the pathogen/stress response, polar auxin transport and development. Transphosphorylates the AGC protein kinases OXI1/AGC2-1, PK1/S6K1, PK19/S6K2 and PID resulting in their activation. Sequence Annotation chain 1 491 3-phosphoinositide-dependent protein kinase 1 domain 44 311 Protein kinase domain 386 491 PH nucleotide phosphate-binding region 50 58 ATP region of interest 77 112 PIF-binding region of interest 185 222 Activation loop active site 167 Proton acceptor binding site 73 ATP modified residue 177 Phosphoserine modified residue 211 Phosphothreonine; by autocatalysis modified residue 276 Phosphoserine modified residue 337 Phosphoserine modified residue 382 Phosphoserine Keyword Alternative splicing,ATP-binding,Complete proteome,Cytoplasm,Kinase,Membrane,Nucleotide-binding,Phosphoprotein,Reference proteome,Serine/threonine-protein kinase,Transferase Sequence Source UniProt Protein Sequence MLAMEKEFDS KLVLQGNSSN GANVSRSKSF SFKAPQENFT SHDFEFGKIY GVGSYSKVVR 60 AKKKETGTVY ALKIMDKKFI TKENKTAYVK LERIVLDQLE HPGIIKLYFT FQDTSSLYMA 120 LESCEGGELF DQITRKGRLS EDEARFYTAE VVDALEYIHS MGLIHRDIKP ENLLLTSDGH 180 IKIADFGSVK PMQDSQITVL PNAASDDKAC TFVGTAAYVP PEVLNSSPAT FGNDLWALGC 240 TLYQMLSGTS PFKDASEWLI FQRIIARDIK FPNHFSEAAR DLIDRLLDTE PSRRPGAGSE 300 GYVALKRHPF FNGVDWKNLR SQTPPKLAPD PASQTASPER DDTHGSPWNL THIGDSLATQ 360 NEGHSAPPTS SESSGSITRL ASIDSFDSRW QQFLEPGESV LMISAVKKLQ KITSKKVQLI 420 LTNKPKLIYV DPSKLVVKGN IIWSDNSNDL NVVVTSPSHF KICTPKKVLS FEDAKQRASV 480 WKKAIETLQN R 491 Gene Ontology GO:0005737; C: cytoplasm; IEA: UniProtKB-SubCell GO:0016020; C: membrane; IEA: UniProtKB-SubCell GO:0004676; F: 3-phosphoinositide-dependent protein kinase activity; IGI: TAIR GO:0005524; F: ATP binding; IEA: UniProtKB-KW GO:0016301; F: kinase activity; ISS: TAIR GO:0070300; F: phosphatidic acid binding; IDA: UniProtKB GO:0035091; F: phosphatidylinositol binding; IDA: TAIR GO:0005515; F: protein binding; IPI: UniProtKB GO:0004672; F: protein kinase activity; IDA: UniProtKB GO:0004674; F: protein serine/threonine kinase activity; IDA: TAIR GO:0045860; P: positive regulation of protein kinase activity; IDA: TAIR GO:0046777; P: protein autophosphorylation; IDA: UniProtKB Interpro Pfam Pfam; PF00069; Pkinase SMART SMART; SM00220; S_TKc PROSITE PRINTS |