UniProt Accession

Q9XIE2; Q8VXW5; AB36G_ARATH 

Theoretical PI

8.08 

Molecular Weight

165082.05 

Genbank Protein ID

BK001007;AY074515;CP002684;AC007258 

Genbank Nucleotide ID

AAD39329.1;AAL67129.1;AEE33632.1;DAA00876.1 

Protein Name

ABC transporter G family member 36; ABC transporter ABCG.36; AtABCG36; Pleiotropic drug resistance protein 8; Protein PENETRATION 3 

Gene Name

ABCG36; PDR8; PEN3; At1g59870; F23H11.19 

Created Date

2006-05-16 

Organism

Arabidopsis thaliana(Mouse-ear cress) 

NCBI Taxa ID

3702 

Phosphorylation Sites

Position	Peptide	Source	References
844	MGRMSRDSAAEASGG	dbPPT, P3DB, PhosPhAt	[14, 15, 4]
43	FSSGSRRTQSVNDDE	dbPPT, P3DB, PhosPhAt	[1, 12, 14, 15, 4, 8]
40	EDIFSSGSRRTQSVN	dbPPT, P3DB, PhosPhAt	[1, 10, 12, 13, 14, 15, 2, 3, 4, 5, 8, 9]
87	VYGNQLMSKEVDVTK	dbPPT, P3DB, PhosPhAt	[14, 3]
38	NIEDIFSSGSRRTQS	dbPPT, P3DB, PhosPhAt	[1, 10, 12, 13, 14, 3, 4, 8]
37	RNIEDIFSSGSRRTQ	dbPPT, P3DB, PhosPhAt	[1, 13, 14, 15, 3, 4, 8]
826	PMRRSLSTADGNRRG	dbPPT, P3DB, PhosPhAt	[1, 13, 14, 3]
960	ISGYCEQTDIHSPQV	dbPPT, P3DB, PhosPhAt	[1, 11, 14]
70	TYSRLRTTLMNAVVE	dbPPT, P3DB, PhosPhAt	[14, 3]
823	GKDPMRRSLSTADGN	dbPPT, P3DB, PhosPhAt	[14, 3]
494	FHVGTKMSNELAVPF	dbPPT, P3DB, PhosPhAt	[1, 14, 15, 4, 5, 7]
825	DPMRRSLSTADGNRR	dbPPT, P3DB, PhosPhAt	[1, 11, 13, 14, 3, 5, 6, 7, 8, 9]
81	AVVEDDVYGNQLMSK	dbPPT, P3DB, PhosPhAt	[14, 3]
63	AAIEKLPTYSRLRTT	dbPPT, P3DB, PhosPhAt	[1, 10, 14, 5, 8, 9]
45	SGSRRTQSVNDDEEA	dbPPT, P3DB, PhosPhAt	[1, 12, 13, 14, 15, 4, 5, 6, 8, 9]
69	PTYSRLRTTLMNAVV	dbPPT, P3DB, PhosPhAt	[14, 3]
841	EVAMGRMSRDSAAEA	dbPPT, P3DB, PhosPhAt	[14, 15, 4]

Functional Description

Key factor that controls the extent of cell death in the defense response. Neccessary for both callose deposition and glucosinolate activation in response to pathogens. Required for limiting invasion by nonadapted powdery mildews. Confers resistance to cadmium (Cd) and lead (Pb), probably as an efflux pump of Cd2+ or Cd conjugates, and possibly, of chemicals that mediate pathogen resistance. 

Sequence Annotation

chain 1 1469 ABC transporter G family member 36
transmembrane region 540 560 Helical;
transmembrane region 575 595 Helical;
transmembrane region 621 641 Helical;
transmembrane region 659 679 Helical;
transmembrane region 685 705 Helical;
transmembrane region 713 733 Helical;
transmembrane region 772 792 Helical;
transmembrane region 1216 1236 Helical;
transmembrane region 1239 1259 Helical;
transmembrane region 1299 1319 Helical;
transmembrane region 1326 1346 Helical;
transmembrane region 1356 1376 Helical;
transmembrane region 1384 1404 Helical;
transmembrane region 1441 1461 Helical;
domain 171 444 ABC transporter 1
domain 522 735 ABC transmembrane type-2 1
domain 867 1119 ABC transporter 2
domain 1192 1406 ABC transmembrane type-2 2
nucleotide phosphate-binding region 204 211 ATP 1
nucleotide phosphate-binding region 912 919 ATP 2
modified residue 1 N-acetylmethionine
modified residue 43 Phosphothreonine
modified residue 45 Phosphoserine

Keyword

Acetylation,ATP-binding,Cell membrane,Complete proteome,Membrane,Nucleotide-binding,Phosphoprotein,Plant defense,Reference proteome,Repeat,Transmembrane,Transmembrane helix,Transport 

Sequence Source

UniProt 

Protein Sequence

Gene Ontology

GO:0009507; C: chloroplast; IDA: TAIR
GO:0009941; C: chloroplast envelope; IDA: TAIR
GO:0016021; C: integral component of membrane; IEA: UniProtKB-KW
GO:0016020; C: membrane; IDA: TAIR
GO:0005739; C: mitochondrion; IDA: TAIR
GO:0005886; C: plasma membrane; IDA: TAIR
GO:0005774; C: vacuolar membrane; IDA: TAIR
GO:0005524; F: ATP binding; IEA: UniProtKB-KW
GO:0016887; F: ATPase activity; IEA: InterPro
GO:0015086; F: cadmium ion transmembrane transporter activity; IDA: TAIR
GO:0070574; P: cadmium ion transmembrane transport; IDA: GOC
GO:0015691; P: cadmium ion transport; IMP: TAIR
GO:0071366; P: cellular response to indolebutyric acid stimulus; IMP: TAIR
GO:0052544; P: defense response by callose deposition in cell wall; IMP: TAIR
GO:0042742; P: defense response to bacterium; IMP: TAIR
GO:0009817; P: defense response to fungus, incompatible interaction; IMP: TAIR
GO:0006855; P: drug transmembrane transport; ISS: TAIR
GO:0042344; P: indole glucosinolate catabolic process; IMP: TAIR
GO:0031348; P: negative regulation of defense response; IMP: TAIR
GO:0009737; P: response to abscisic acid; IDA: TAIR
GO:0009627; P: systemic acquired resistance; IMP: TAIR 

Interpro

InterPro; IPR003593; AAA+_ATPase
InterPro; IPR013525; ABC_2_trans
InterPro; IPR029481; ABC_trans_N
InterPro; IPR003439; ABC_transporter-like
InterPro; IPR027417; P-loop_NTPase
InterPro; IPR013581; PDR_assoc

Pfam

Pfam; PF01061; ABC2_membrane
Pfam; PF00005; ABC_tran
Pfam; PF14510; ABC_trans_N
Pfam; PF08370; PDR_assoc 

SMART

SMART; SM00382; AAA 

PROSITE

PS50893; ABC_TRANSPORTER_2 

PRINTS