※ dbPPT Protein Information
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UniProt Accession | |||||||||||||||||||||||||||||||||||
Theoretical PI | 5.4 | ||||||||||||||||||||||||||||||||||
Molecular Weight | 82364.72 | ||||||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||||||
Protein Name | DNA mismatch repair protein MLH1; MutL protein homolog 1; Protein MUTL-HOMOLOGUE 1; AtMLH1 | ||||||||||||||||||||||||||||||||||
Gene Name | MLH1; At4g09140; F23J3.170; T8A17.9 | ||||||||||||||||||||||||||||||||||
Created Date | 2013-04-03 | ||||||||||||||||||||||||||||||||||
Organism | Arabidopsis thaliana(Mouse-ear cress) | ||||||||||||||||||||||||||||||||||
NCBI Taxa ID | 3702 | ||||||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description Involved in DNA mismatch repair (MMR), correcting insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage or from recombination events between non-identical sequences during meiosis. Component of the MutLbeta heterodimer, which probably forms a ternary complex with the MutSbeta heterodimer that initially recognizes the DNA mismatches. This complex is thought to be responsible for directing the downsteam MMR events, including strand discrimination, excision, and resynthesis. Plays a major role in promoting meiotic crossing-over and is involved in maintaining the genetic stability of simple sequence repeats by correction of frameshift intermediates. Sequence Annotation chain 1 737 DNA mismatch repair protein MLH1 compositionally biased region 10 15 Poly-Glu Keyword Complete proteome,DNA damage,DNA repair,Nucleus,Reference proteome Sequence Source UniProt Protein Sequence MIDDSSLTAE MEEEESPATT IVPREPPKIQ RLEESVVNRI AAGEVIQRPV SAVKELVENS 60 LDADSSSISV VVKDGGLKLI QVSDDGHGIR REDLPILCER HTTSKLTKFE DLFSLSSMGF 120 RGEALASMTY VAHVTVTTIT KGQIHGYRVS YRDGVMEHEP KACAAVKGTQ IMVENLFYNM 180 IARRKTLQNS ADDYGKIVDL LSRMAIHYNN VSFSCRKHGA VKADVHSVVS PSRLDSIRSV 240 YGVSVAKNLM KVEVSSCDSS GCTFDMEGFI SNSNYVAKKT ILVLFINDRL VECSALKRAI 300 EIVYAATLPK ASKPFVYMSI NLPREHVDIN IHPTKKEVSL LNQEIIIEMI QSEVEVKLRN 360 ANDTRTFQEQ KVEYIQSTLT SQKSDSPVSQ KPSGQKTQKV PVNKMVRTDS SDPAGRLHAF 420 LQPKPQSLPD KVSSLSVVRS SVRQRRNPKE TADLSSVQEL IAGVDSCCHP GMLETVRNCT 480 YVGMADDVFA LVQYNTHLYL ANVVNLSKEL MYQQTLRRFA HFNAIQLSDP APLSELILLA 540 LKEEDLDPGN DTKDDLKERI AEMNTELLKE KAEMLEEYFS VHIDSSANLS RLPVILDQYT 600 PDMDRVPEFL LCLGNDVEWE DEKSCFQGVS AAIGNFYAMH PPLLPNPSGD GIQFYSKRGE 660 SSQEKSDLEG NVDMEDNLDQ DLLSDAENAW AQREWSIQHV LFPSMRLFLK PPASMASNGT 720 FVKVASLEKL YKIFERC 737 Gene Ontology GO:0005712; C: chiasma; IBA: RefGenome GO:0032389; C: MutLalpha complex; IBA: RefGenome GO:0032390; C: MutLbeta complex; IBA: RefGenome GO:0000790; C: nuclear chromatin; IDA: TAIR GO:0000795; C: synaptonemal complex; IBA: RefGenome GO:0005524; F: ATP binding; IEA: InterPro GO:0016887; F: ATPase activity; IBA: RefGenome GO:0030983; F: mismatched DNA binding; IBA: RefGenome GO:0006200; P: ATP catabolic process; IBA: RefGenome GO:0010154; P: fruit development; IMP: TAIR GO:0006298; P: mismatch repair; IBA: RefGenome GO:0006312; P: mitotic recombination; IMP: TAIR GO:0009555; P: pollen development; IMP: TAIR GO:0007131; P: reciprocal meiotic recombination; IBA: RefGenome GO:0048316; P: seed development; IMP: TAIR GO:0009845; P: seed germination; IMP: TAIR Interpro InterPro; IPR013507; DNA_mismatch_repair_C InterPro; IPR014762; DNA_mismatch_repair_CS InterPro; IPR002099; DNA_mismatch_repair_fam InterPro; IPR011186; DNA_mismatch_repair_MLH1/HexB InterPro; IPR003594; HATPase_ATP-bd InterPro; IPR020568; Ribosomal_S5_D2-typ_fold InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr Pfam SMART SMART; SM00387; HATPase_c PROSITE PS00058; DNA_MISMATCH_REPAIR_1 PRINTS |