※ dbPPT Protein Information
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UniProt Accession | |||||||||||||||||||||||||||||||
Theoretical PI | 7.9 | ||||||||||||||||||||||||||||||
Molecular Weight | 85313.05 | ||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||
Protein Name | Cullin-3A; AtCUL3a | ||||||||||||||||||||||||||||||
Gene Name | CUL3A; CUL3; At1g26830; T2P11.2 | ||||||||||||||||||||||||||||||
Created Date | 2010-08-10 | ||||||||||||||||||||||||||||||
Organism | Arabidopsis thaliana(Mouse-ear cress) | ||||||||||||||||||||||||||||||
NCBI Taxa ID | 3702 | ||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description Component of the cullin-RING ubiquitin ligases (CRL), or CUL3-RBX1-BTB protein E3 ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the CRL complex depends on the BTB domain-containing protein as the susbstrate recognition component. Involved in embryo pattern formation and endosperm development. Required for the normal division and organization of the root stem cells and columella root cap cells. Regulates primary root growth by an unknown pathway, but in an ethylene-dependent manner. Functions in distal root patterning, by an ethylene-independent mechanism. Functionally redundant with CUL3B. Sequence Annotation chain 1 732 Cullin-3A cross-link 676 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8) Keyword Complete proteome,Isopeptide bond,Reference proteome,Ubl conjugation,Ubl conjugation pathway Sequence Source UniProt Protein Sequence MSNQKKRNFQ IEAFKHRVVV DPKYADKTWQ ILERAIHQIY NQDASGLSFE ELYRNAYNMV 60 LHKFGEKLYT GFIATMTSHL KEKSKLIEAA QGGSFLEELN KKWNEHNKAL EMIRDILMYM 120 DRTYIESTKK THVHPMGLNL WRDNVVHFTK IHTRLLNTLL DLVQKERIGE VIDRGLMRNV 180 IKMFMDLGES VYQEDFEKPF LDASSEFYKV ESQEFIESCD CGDYLKKSEK RLTEEIERVA 240 HYLDAKSEEK ITSVVEKEMI ANHMQRLVHM ENSGLVNMLL NDKYEDLGRM YNLFRRVTNG 300 LVTVRDVMTS HLREMGKQLV TDPEKSKDPV EFVQRLLDER DKYDKIINTA FGNDKTFQNA 360 LNSSFEYFIN LNARSPEFIS LFVDDKLRKG LKGITDVDVE VILDKVMMLF RYLQEKDVFE 420 KYYKQHLAKR LLSGKTVSDD AERSLIVKLK TECGYQFTSK LEGMFTDMKT SEDTMRGFYG 480 SHPELSEGPT LIVQVLTTGS WPTQPAVPCN LPAEVSVLCE KFRSYYLGTH TGRRLSWQTN 540 MGTADIKAIF GKGQKHELNV STFQMCVLML FNNSDRLSYK EIEQATEIPA ADLKRCLQSL 600 ACVKGKNVIK KEPMSKDIGE EDLFVVNDKF TSKFYKVKIG TVVAQKETEP EKQETRQRVE 660 EDRKPQIEAA IVRIMKSRKI LDHNNIIAEV TKQLQPRFLA NPTEIKKRIE SLIERDFLER 720 DSTDRKLYRY LA 732 Gene Ontology GO:0031461; C: cullin-RING ubiquitin ligase complex; IEA: InterPro GO:0005829; C: cytosol; IDA: TAIR GO:0005515; F: protein binding; IPI: UniProtKB GO:0009793; P: embryo development ending in seed dormancy; IGI: TAIR GO:0009960; P: endosperm development; IGI: TAIR GO:0009911; P: positive regulation of flower development; IMP: TAIR GO:0009639; P: response to red or far red light; IMP: TAIR GO:0006511; P: ubiquitin-dependent protein catabolic process; IEA: InterPro Interpro Pfam SMART PROSITE PS50069; CULLIN_2 PRINTS |