UniProt Accession

Q9ZWC8; C0LGH1; BRL1_ARATH 

Theoretical PI

6.97 

Molecular Weight

127424.03 

Genbank Protein ID

FJ708660;AC002328;CP002684 

Genbank Nucleotide ID

AEE33272.1;AAF79510.1;ACN59256.1;AEE33271.1 

Protein Name

Serine/threonine-protein kinase BRI1-like 1; BRASSINOSTEROID INSENSITIVE 1-like protein 1 

Gene Name

BRL1; At1g55610; F20N2.4 

Created Date

2005-01-04 

Organism

Arabidopsis thaliana(Mouse-ear cress) 

NCBI Taxa ID

3702 

Phosphorylation Sites

Position	Peptide	Source	References
1101	PELVTDKSGDVELFH	dbPPT, P3DB, PhosPhAt	[1, 2, 4, 5, 6]
823	LPTSGSCSWKLSSVP	dbPPT, P3DB, PhosPhAt	[2, 4, 5]
1141	FKEMKADTEEDESLD	dbPPT, P3DB, PhosPhAt	[3, 4, 6, 7]
1146	ADTEEDESLDEFSLK	dbPPT, P3DB, PhosPhAt	[2, 3, 4, 5, 6]

Functional Description

Receptor with a serine/threonine-protein kinase activity. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development. Binds brassinolide. May be involved in cell growth and vascular differentiation. 

Sequence Annotation

signal peptide 1 21
chain 22 1166 Serine/threonine-protein kinase BRI1-like 1
topological domain 22 776 Extracellular
transmembrane region 777 797 Helical;
topological domain 798 1166 Cytoplasmic
repeat 78 99 LRR 1
repeat 103 124 LRR 2
repeat 126 147 LRR 3
repeat 152 173 LRR 4
repeat 176 197 LRR 5
repeat 202 224 LRR 6
repeat 227 248 LRR 7
repeat 252 274 LRR 8
repeat 278 300 LRR 9
repeat 303 325 LRR 10
repeat 327 349 LRR 11
repeat 352 375 LRR 12
repeat 376 397 LRR 13
repeat 403 424 LRR 14
repeat 427 449 LRR 15
repeat 451 473 LRR 16
repeat 476 498 LRR 17
repeat 500 522 LRR 18
repeat 524 547 LRR 19
repeat 548 570 LRR 20
repeat 664 686 LRR 21
repeat 688 710 LRR 22
repeat 712 734 LRR 23
domain 859 1147 Protein kinase
nucleotide phosphate-binding region 865 873 ATP
short sequence motif 66 73 Cys pair 1
short sequence motif 748 755 Cys pair 2
active site 987 Proton acceptor
binding site 887 ATP
modified residue 848 Phosphothreonine
modified residue 856 Phosphothreonine
modified residue 932 Phosphotyrosine
modified residue 1141 Phosphothreonine
glycosylation site 33 N-linked (GlcNAc...)
glycosylation site 97 N-linked (GlcNAc...)
glycosylation site 157 N-linked (GlcNAc...)
glycosylation site 212 N-linked (GlcNAc...)
glycosylation site 227 N-linked (GlcNAc...)
glycosylation site 237 N-linked (GlcNAc...)
glycosylation site 257 N-linked (GlcNAc...)
glycosylation site 362 N-linked (GlcNAc...)
glycosylation site 373 N-linked (GlcNAc...)
glycosylation site 451 N-linked (GlcNAc...)
glycosylation site 461 N-linked (GlcNAc...)
glycosylation site 521 N-linked (GlcNAc...)
glycosylation site 532 N-linked (GlcNAc...)
glycosylation site 558 N-linked (GlcNAc...)
glycosylation site 638 N-linked (GlcNAc...)
glycosylation site 722 N-linked (GlcNAc...)
glycosylation site 743 N-linked (GlcNAc...)
helix 33 44
strand 46 48
turn 53 56
helix 65 67
strand 71 73
strand 79 83
strand 90 93
helix 95 99
strand 106 108
strand 111 116
strand 128 131
strand 134 137
helix 140 149
strand 155 157
strand 164 166
strand 179 181
strand 184 190
turn 193 198
strand 205 207
strand 214 216
helix 217 219
strand 230 232
strand 235 239
helix 247 249
strand 255 257
turn 270 275
strand 281 283
strand 290 292
helix 295 302
strand 305 308
helix 320 324
strand 330 332
strand 335 338
helix 342 345
helix 347 349
strand 355 357
strand 364 366
helix 369 373
strand 379 381
strand 384 389
strand 395 398
strand 406 408
helix 420 424
strand 430 432
strand 439 441
helix 444 447
strand 454 456
strand 459 464
turn 468 472
strand 478 481
helix 493 497
strand 503 505
helix 517 521
strand 527 529
helix 541 545
strand 551 553
strand 556 559
helix 565 568
turn 569 573
turn 578 581
strand 583 590
turn 594 597
strand 598 603
helix 609 614
turn 616 620
strand 623 630
strand 636 639
strand 642 645
strand 652 654
helix 657 661
strand 667 669
helix 681 685
strand 690 693
strand 696 701
helix 705 709
strand 715 717
strand 720 723
helix 733 735
helix 738 741
strand 745 749

Keyword

3D-structure,ATP-binding,Cell membrane,Complete proteome,Glycoprotein,Kinase,Leucine-rich repeat,Lipid-binding,Membrane,Nucleotide-binding,Phosphoprotein,Receptor,Reference proteome,Repeat,Serine/threonine-protein kinase,Signal,Steroid-binding,Transferase,Transmembrane,Transmembrane helix 

Sequence Source

UniProt 

Protein Sequence

Gene Ontology

GO:0016021; C: integral component of membrane; IEA: UniProtKB-KW
GO:0005886; C: plasma membrane; IDA: TAIR
GO:0005524; F: ATP binding; IEA: UniProtKB-KW
GO:0005515; F: protein binding; IPI: IntAct
GO:0004674; F: protein serine/threonine kinase activity; IEA: UniProtKB-KW
GO:0005496; F: steroid binding; IEA: UniProtKB-KW 

Interpro

InterPro; IPR013320; ConA-like_subgrp
InterPro; IPR011009; Kinase-like_dom
InterPro; IPR001611; Leu-rich_rpt
InterPro; IPR013210; LRR-contain_N2
InterPro; IPR000719; Prot_kinase_dom
InterPro; IPR017441; Protein_kinase_ATP_BS
InterPro; IPR008271; Ser/Thr_kinase_AS

Pfam

Pfam; PF00560; LRR_1
Pfam; PF13855; LRR_8
Pfam; PF08263; LRRNT_2
Pfam; PF00069; Pkinase 

SMART

 

PROSITE

PS51450; LRR
PS00107; PROTEIN_KINASE_ATP
PS50011; PROTEIN_KINASE_DOM
PS00108; PROTEIN_KINASE_ST 

PRINTS