※ dbPPT Protein Information
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UniProt Accession | |||||||||||||||||||||||||||||||
Theoretical PI | 5.59 | ||||||||||||||||||||||||||||||
Molecular Weight | 52045.02 | ||||||||||||||||||||||||||||||
Genbank Protein ID | |||||||||||||||||||||||||||||||
Genbank Nucleotide ID | |||||||||||||||||||||||||||||||
Protein Name | Inosine-5'-monophosphate dehydrogenase; IMP dehydrogenase; IMPD; IMPDH | ||||||||||||||||||||||||||||||
Gene Name | |||||||||||||||||||||||||||||||
Created Date | 2014-03-19 | ||||||||||||||||||||||||||||||
Organism | Triticum aestivum(Wheat) | ||||||||||||||||||||||||||||||
NCBI Taxa ID | 4565 | ||||||||||||||||||||||||||||||
Phosphorylation Sites |
Functional Description Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity). Sequence Annotation domain 163 222 CBS nucleotide phosphate-binding region 259 261 NAD nucleotide phosphate-binding region 309 311 NAD region of interest 349 351 IMP binding region of interest 372 373 IMP binding region of interest 396 400 IMP binding active site 316 Thioimidate intermediate metal ion-binding site 311 Potassium; via carbonyl oxygen metal ion-binding site 313 Potassium; via carbonyl oxygen metal ion-binding site 316 Potassium; via carbonyl oxygen binding site 314 IMP binding site 424 IMP Keyword CBS domain,Complete proteome,Cytoplasm,GMP biosynthesis,Metal-binding,NAD,Oxidoreductase,Potassium,Purine biosynthesis Sequence Source UniProt Protein Sequence MASLADDGFS AARLFSQGVS YTYDDVIFLP GFIDFPADAV DLSTRLSRRV PLSIPCVASP 60 MDTVSEAAMA AAMASLGGVA VVHSNTEPRA QASIVRAAKS RRLPFVSSVP IFSPASAPTL 120 NDFAGHDYAL VTEQGDSLSK LLGVAVAADA ASPEAPAPVS EYMRPAPRSA SASFDFEQAA 180 AFLADEGLDY APLVSEEGEV IDLITSKDVE RIRSYPKLGK PSLGADGKFV VAASIGTRED 240 DKLRLEQLIQ AGANAIVIDS SQGNSTYQLD MIKYAKKTFP EVDLIGGNVV TIGQAQNLIA 300 AGVDGLRVGM GSGSICTTQE VCAVGRGQAT AVYKVASYAK DHNVPVIADG GISYSGHIVK 360 ALSLGASTVM MGSFLAGSHE APGAYEYKDG HRVKKYRGMG SLEAMTKGSD ARYLGDTLKL 420 KVAQGVVGAV ADKGSVLRFI PYTMQAVKQG FQDLGASSLQ SAHDLLRAET LRLEVRTGAA 480 QVEGGIHGLV SYEKKSF 497 Gene Ontology GO:0005737; C: cytoplasm; IEA: UniProtKB-HAMAP GO:0030554; F: adenyl nucleotide binding; IEA: InterPro GO:0003938; F: IMP dehydrogenase activity; IEA: UniProtKB-HAMAP GO:0046872; F: metal ion binding; IEA: UniProtKB-HAMAP GO:0006177; P: GMP biosynthetic process; IEA: UniProtKB-HAMAP Interpro Pfam SMART SMART; SM00116; CBS PROSITE PRINTS |